WTX beyond WNT signaling pathway

Gastric cancer (GC) is a major malignancy in many developing countries with low early detection rate. As tumour suppressor gene, WTX inhibits PI3K/AKT/mTOR pathway activity by inhibiting PI3K phosphorylation. loss of protein associates tumor metastasis and poor survival GC patients. During progression, an aberrantly elevated miR-20a-5p expression has been found, which induces phosphorylation, thereby activating the promoting cellular proliferation migration. A new mechanism promotes progression regulating to control recently discovered. These findings might be useful for novel therapeutics inhibit GC.